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Lehrende/r: Dr. Udo Birk; Prof. Dr. Christoph Cremer
Veranstaltungsart:
Vorlesung/Übung/Praktikum
Anzeige im Stundenplan:
Grundl.biomed.Optik
Semesterwochenstunden:
4
Credits:
6,0
Unterrichtssprache:
Englisch
Min. | Max. Teilnehmerzahl:
- | -
Voraussetzungen / Organisatorisches:
Investigating structural (morphological), functional, and molecular features of the human body (or of parts thereof) on the one hand is ubiquitously used in modern diagnosis and treatment of diseases. Resolving structural features at the molecular scale on the other hand is absolutely essential for harnessing the power of nanotechnology and exploring the unique hierarchical structure of complex biological systems, i.e. of cells and even of subcellular structures that organisms are composed of.
In this first half of a two semester course, we focus on the main optical concepts of imaging and the general technical aspects (e.g. hardware instrumentation used). In the next term, details of specific optical imaging techniques and their application in biology and medicine will be discussed.
The course is divided in a lecture part (2h/week), a tutorial (1h/week), and a practical lab (3day block lab) on advanced microscopy. The tutorial is aimed at providing the basis for quantitative image analysis in biomedical optics. For this, we will be using the MATLAB programming environment.
Lectures: Tuesday, 14:15-15:45, IMB Mainz, Ackermannweg 4, Seminarroom 2nd floor.
Tutorials: Wednesday, 14:15-15:00, Institut für Physik, Staudingerweg, CIP pool.
Labs: Block course March 10-12, full day.
This course requires at least a basic knowledge in electromagnetics/optics and will be taught at the post-baccalaureate level. The course language is English, unless otherwise specified.
Inhalt:
In this first half of a two semester course, we focus on the main optical concepts of imaging and the general technical aspects (e.g. hardware instrumentation used). After an introduction to the electromagnetic concepts of light and its interaction with tissue, we will discuss recent development in technical optics (e.g. light sources, detectors) making possible the huge progress that biomedical imaging has recently seen. Several conceptual models representing (and simplifying) the optical image formation process will be discussed. Reasons for limitations in image resolution will be given, and means to overcome the technical problems will be discussed. The course will be complemented by a brief historical outline.
In the next term (Basics of Biomedical Optics 2), details of specific optical imaging techniques and their application in biology and medicine will be discussed. We will present very recent developments in imaging wherein 150-year old physical limits have been overcome and where true molecular resolution has been accomplished. Students will be exposed to cutting edge approaches to molecular resolution in linear and nonlinear microscopy, which are uniquely available in Mainz at the Institute for Molecular Biology. Also in the second part, specifics of the optical imaging in medical environment will be discussed e.g., imaging of whole bodies, clinical and pre-clinical imaging, photoacoustics, and tomographic approaches.
More information can be found on the course webpage: http://www.optics.imb-mainz.de/teach/2013B-biomedical-optics.php
Empfohlene Literatur:
Saleh/Teich: Fundamentals of Photonics, Wiley
Hecht: Optics, Addison-Wesley
Born/Wolf: Principles of Optics, Cambridge University Press
Gu: Advanced Optical Imaging Theory, Springer
Ripoll: Principles of Diffuse Light Propagation, World Scientific
Zusätzliche Informationen:
Course webpage: http://www.optics.imb-mainz.de/teach/2013B-biomedical-optics.php
Contact: Dr. Udo Birk (E-mail: u.birk[at]imb-mainz.de)
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