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Instructors: Dr. Udo Birk; Prof. Dr. Christoph Cremer
Event type:
Lecture/practice class/work placement
Displayed in timetable as:
Grundl.biomed.Optik2
Hours per week:
4
Credits:
6,0
Language of instruction:
Englisch
Min. | Max. participants:
- | -
Requirements / organisational issues:
Investigating structural (morphological), functional, and molecular features of the human body (or of parts thereof) on the one hand is ubiquitously used in modern diagnosis and treatment of diseases. Resolving structural features at the molecular scale on the other hand is absolutely essential for harnessing the power of nanotechnology and exploring the unique hierarchical structure of complex biological systems, i.e. of cells and even of subcellular structures that organisms are composed of.
In this second half of a two semester course, we focus on details of specific techniques of optical imaging, laser spectroscopy, and optical metrology, as well as their application in biology and medicine. The main optical concepts of imaging and the general technical aspects (e.g. hardware instrumentation used) were discussed in the first course Basics of Biomedical Optics 1.
The course is divided in a lecture part (2h/week), a tutorial (1h/week), and a practical lab (3day block lab) on advanced microscopy. The tutorial is aimed at providing the basis for quantitative image analysis in biomedical optics. For this, we will be using the MATLAB programming environment.
Lectures: Tuesday, 14:15-15:45, IMB Mainz, Ackermannweg 4, Seminarroom 2nd floor.
Tutorials: Wednesday, 13:15-15:00, Institut für Physik, Staudingerweg, CIP pool.
Labs: Block course August 05-07 (tbc, see course webpage), full day.
This course will be taught at the post-baccalaureate level. A basic knowledge in electromagnetics/optics is helpful, but not strictly required, since all relevant topics will be covered to provide enough background. The course language is English, unless otherwise specified.
Contents:
In Basics of Biomedical Optics 1 (previous course in winter term 2013/2014), i.e. in the first half of this two semester course, the main optical concepts of imaging and general technical aspects for realization of optical imaging devices are in focus. After an introduction to the electromagnetic concepts of light and its interaction with tissue, we will discuss recent development in technical optics (e.g. light sources, detectors) making possible the huge progress that biomedical imaging has recently seen. Several conceptual models representing (and simplifying) the optical image formation process will be discussed. Reasons for limitations in image resolution will be given, and means to overcome the technical problems will be presented. Contrasting mechanisms of optical imaging will be discussed and first approaches to enhance the 3D resolution in microscopy. The course will be complemented by a brief historical outline.
In Basics of Biomedical Optics 2 (i.e. in the second term in summer 2014), details of specific techniques of optical imaging, laser spectroscopy, and optical metrology, as well as their application in biology and medicine will be discussed. Recent developments in microscopic imaging techniques will be presented wherein 150-year old physical limits have been overcome and where true molecular resolution has been accomplished. Students will be exposed to cutting edge approaches to molecular resolution in linear and nonlinear optical microscopy, which are uniquely available in Mainz at the Institute for Molecular Biology. These purely optical imaging approaches will be complemented by an introduction to photoacoustic imaging and detection. Also in the second part, specifics of medical imaging and laser applications in diagnostics and therapy will be discussed e.g., imaging of whole bodies, clinical and pre-clinical imaging, and tomographic approaches. Image reconstruction including deconvolution approaches will also be presented in this second term.
More information can be found on the course webpage: http://www.optics.imb-mainz.de/teach/2014A-biomedical-optics-2.php
Recommended reading list:
E. Saleh, M. Teich: Fundamentals of Photonics, Wiley
E. Hecht: Optics, Addison-Wesley
M. Born, E. Wolf: Principles of Optics, Cambridge University Press
M. Gu: Advanced Optical Imaging Theory, Springer
J. Ripoll: Principles of Diffuse Light Propagation, World Scientific
D. Boas, C. Pitris, N. Ramanujam: Handbook of Biomedical Optics, CRC Press
J. Bille, W. Schlegel: Medizinische Physik 3, Springer (German only)
Additional information:
Course webpage for term1: http://www.optics.imb-mainz.de/teach/2013B-biomedical-optics.php
Course webpage for term2: http://www.optics.imb-mainz.de/teach/2014A-biomedical-optics-2.php
Contact: Dr. Udo Birk (E-mail: u.birk[at]imb-mainz.de)
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